Simply create a GridFlair block. Specify the number of grids then specify the breakpoint.
<div class="gridflair">
<div class="set6grid break_at_320">Column One</div>
<div class="set6grid break_at_320">Column Two</div>
</div>
<div class="gridflair">
<div class="set6grid break_at_1000">Column One</div>
<div class="set3grid break_at_1000">Column Two</div>
<div class="set3grid break_at_1000">Column Three</div>
</div>
<div class="gridflair">
<div class="set6grid break_at_320">Column One</div>
<div class="set6grid break_at_320">
<!-- GridFlair block inside another GridFlair block -->
<div class="gridflair">
<div class="set6grid break_at_580">Column One</div>
<div class="set6grid break_at_580">Column Two</div>
</div>
</div>
</div>